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Molecular basis of Rho activation during CR3 (alphaM beta2)-mediated phagocytosis
Reference
C18637
Principal Investigator / Supervisor
Dr Emmanuelle Caron
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
186,444
Status
Completed
Type
Research Grant
Start date
03/06/2003
End date
02/05/2007
Duration
47 months
Abstract
Rho GTPases control actin cytoskeleton remodelling in response to diverse extracellular signals. However, the signalling pathways linking surface receptors to GTPases remain unclear. We have shown that Rho activity is specifically required for actin polymerisation and phagocytosis downstream of the integrin alpha M bet a2 (aka CR3), a receptor that directs uptake of both microorganisms, and apoptotic cells in mammals. We will combine site-directed mutagenesis on the integrin intracellular tails, Rho-GTP pull-downs and pharmacological, cellular and biochemical approaches to dissect the signalling pathway(s) linking phagocytic ligation of alpha M beta 2 to Rho recruitment and activation. Our work will identify the main regulator(s) - starting with a candidate Rho GEF- that control alpha M beta 2-induced signalling to the cytoskeleton, a pathway central to phagocytosis, adhesion and motility.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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