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MAL-related protein and an interacting partner CRHSP28: analysis of their role in lipid raft- mediated protein targeting
Reference
C18632
Principal Investigator / Supervisor
Dr Kath Shennan
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
School of Medical Sciences
Funding type
Research
Value (£)
222,784
Status
Completed
Type
Research Grant
Start date
01/08/2003
End date
30/09/2006
Duration
38 months
Abstract
Lipid rafts play a crucial role in diverse cell processes including protein targeting. Some proteins that form complexes with lipid rafts (e.g. MAL in kidney epithelial cells) may play regulatory roles in raft-mediated function. Cytosolic proteins that interact with lipid raft complexes will be vital for the diversity of functions observed. We have identified a MAL homologue, MRP, that has a more widespread distribution and is likely to have a more ubiquitous role in lipid raft-mediated function than MAL. MRP interacts with a cytosolic protein, CRHSP28, that has been proposed to function in secretagogue-mediated protein secretion. The aim of the proposal is to define a role for both MRP and CRHSP28 in lipid raft-mediated protein secretion.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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