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Proteolipid protein gene dosage and myelination
Reference
C18627
Principal Investigator / Supervisor
Professor Ian Griffiths
Co-Investigators /
Co-Supervisors
Dr Thomas Anderson
,
Dr Mark McLaughlin
Institution
University of Glasgow
Department
Veterinary School
Funding type
Research
Value (£)
214,760
Status
Completed
Type
Research Grant
Start date
21/06/2003
End date
20/06/2006
Duration
36 months
Abstract
Increased dosage of the myelin proteolipid protein (Plp) gene disrupts the co-ordinate programme of myelin gene expression and leads to dysmyelination or demyelination. The increased expression of the Plp gene does, in some circumstances, result in changes in levels of other proteins within the myelin sheath, suggesting local regulatory mechanisms. Morphological evidence suggests that excess PLP is degraded via the lysosomal system. This study examines the dynamics of PLP processing in the presence of increased gene dosage and the effect of this upon other key myelin proteins. The study provides a model in which to explore the complex gene interactions necessary to generate the myelin sheath in a highly specialised cell type.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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