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Transdifferentiated hepatocytes as a model for studying liver function
Reference
C18601
Principal Investigator / Supervisor
Professor David Tosh
Co-Investigators /
Co-Supervisors
Institution
University of Bath
Department
Biology and Biochemistry
Funding type
Research
Value (£)
189,656
Status
Completed
Type
Research Grant
Start date
01/07/2003
End date
30/11/2006
Duration
41 months
Abstract
Numerous attempts have been made in the past to establish long- term cultures of hepatocytes with the aim of producing an experimental system suitable for studying liver function. The systems currently available either exhibit rapid dedifferentiation of hepatocyte-specific genes or, the cell lines that are in use do not possess the full complement of liver functions. We plan to overcome these problems by using hepatocytes produced from pancreatic cells in a process termed transdifferentiation. The purpose of the present proposal is to characterise the potential of transdifferentiated hepatocytes as a model for liver function based on expression studies and functional analyses of hepatic proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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