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Functional analysis of FtsH homologues in photosynthetic organisms

Reference	C18535
Principal Investigator / Supervisor	Professor Nicholas Mann
Co-Investigators / Co-Supervisors	Professor Colin Robinson
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	198,448
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/04/2006
Duration	36 months

Abstract

Members of the FtsH family of proteins act as chaperones for assembly of newly synthesised and transported proteins into oligomeric complexes, and in the rapid degradation of unassembled, unfolded or damaged membrane proteins. Photosynthetic organisms have multiple FtsH homologues, one of which has already been shown to be required for the functional integrity of the photosynthetic apparatus. These FtsH homologues share conserved modules in their N-termini. The proposed research addresses the questions of why do oxygenic photosynthetic organisms, both plants and cyanobacteria, possess multiple FtsH homologues and what is the functional significance of the conserved modules in the N-termini of these proteins.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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