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Investigating the mechanism by which tissue inhibitor of metalloproteinase-1 (TIMP-1) is neuroprotective
Reference
C18365
Principal Investigator / Supervisor
Professor James Uney
Co-Investigators /
Co-Supervisors
Professor Jeremy Henley
Institution
University of Bristol
Department
Physiology and Pharmacology
Funding type
Research
Value (£)
170,388
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
30/09/2006
Duration
42 months
Abstract
Results obtained in a previous study have lead us to hypothesise that TIMP-1 may protect neurons from excitotoxic damage by inhibiting glutamate mediated calcium influx into neurones. The main aims of this study are: to investigate whether: (i) TIMP-1 is inhibiting calcium influx via an effect on the trafficking and or function of NMDA or AMPA and Kainate receptors; (ii) use TIMP-1 mutants to confirm that TIMP-1 mediates neuroprotective effects independently of its actions on matrix metalloproteinases (MMPs); (iii) examine the significance of interactions between TIMP-1 and known cellular proteins identified by yeast two-hybrid analysis.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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