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A novel pathway for thylakoid membrane protein insertion
Reference
C18313
Principal Investigator / Supervisor
Professor Colin Robinson
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
221,988
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
The overall aim of this research is to understand how hydrophobic proteins integrate into biological membranes. We have recently defined a novel insertion pathway that is used by the vast majority of chloroplast thylakoid membrane proteins. This pathway is unique in that insertion does not require any of the known protein targeting apparatus, including the Oxa1-type proteins that are critical in bacterial and mitochondrial systems studied to date. The first aim is to determine whether protein insertion is mediated by thylakoid-type lipids or novel protein transport machinery. The insertion reaction will then be analysed in detail to identify and characterise the lipids and proteins involved. Thirdly, we will test whether this novel pathway operates in cyanobacterial thylakoids by mutagenesis of the gene encoding the Oxa1 homologue in Synechocystis.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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