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Growth-signalling pathway in Arabidopsis involving phosphatidic acid PDK1 and PKA-like protein kinases
Reference
C18199
Principal Investigator / Supervisor
Professor Laszlo Bogre
Co-Investigators /
Co-Supervisors
Dr R Anthony
Institution
Royal Holloway, Univ of London
Department
Biological Sciences
Funding type
Research
Value (£)
240,180
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/12/2006
Duration
45 months
Abstract
Despite its central importance in biomass production and sustainable agriculture, we have little understanding of how plant hormones regulate growth. Recently, we discovered a novel phospholipid- signalling cascade that responds to auxin and cytokinin, the two major growth hormones in plants, and involves phosphatidic acid (PA), 3- phosphoinositide-dependent protein kinase 1 (PDK1) and a protein kinase A (PKA)-like protein. We propose: (1) to genetically delineate the pathway and establish the physiological functions for AtPDK1 and AtPKA2 in Arabidopsis, using RNAi, insertional and dominant negative mutants (2) to study the mechanisms by which AtPDK1 and AtPKA2 are regulated by lipids, protein interactions, phosphorylation and by localisation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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