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Formation of a multi-component complex regulates phosphatidylcholine hydrolysis cell shape and secretion
Reference
C18166
Principal Investigator / Supervisor
Dr Matthew Hodgkin
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
189,112
Status
Completed
Type
Research Grant
Start date
15/02/2003
End date
15/02/2006
Duration
36 months
Abstract
Acute inflammatory conditions promote mast cells to release various inflammatory mediators. The process is promoted through cross- linking of the Immunoglobulin E (IgE) receptor and activation of intracellular signalling cascades. We have shown previously that antigen stimulation of mast cells results in activation of phospholipase D and that inhibition of phospholipase D inhibits mediator secretion. Many PLD functions can be ascribed to the promotion of remodelling of the actin cytoskeleton. We have recently identified a novel receptor-dependent association of PLD1 with F-actin in mast cells and this project is focussed on determining how this process is regulated and the physiological consequences.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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