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Spectrin in the process of neurite outgrowth
Reference
C18062
Principal Investigator / Supervisor
Dr Anthony Baines
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
229,504
Status
Completed
Type
Research Grant
Start date
01/05/2003
End date
01/05/2006
Duration
36 months
Abstract
Genetic and cell biological data make it clear that spectrin is essential for the outgrowth of axonal processes from nerve cells, but the mechanism is unknown. The aim of this project is to investigate the mechanisms linking spectrin to neurite outgrowth. Deliverables: spectrin isoforms and organisation in growth ones (by month 14); phosphate-sensitive antibodies to spectrin tyrosine phosphorylation sites (by month 16); identification of spectrin regions recruiting and retaining it in growth cones (by month 22); analysis of spectrin tyrosine phosphorylation and calpain cleavage in growth cones (by month 28); identification of growth cone ligands for spectrin (by month 36).
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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