Award details

Regulation of transcription initiation and elongation by the androgen receptor

Reference	C18001
Principal Investigator / Supervisor	Professor Iain McEwan
Co-Investigators / Co-Supervisors	Dr Andrew Ball
Institution	University of Aberdeen
Department	School of Medical Sciences
Funding type	Research
Value (£)	183,800
Status	Completed
Type	Research Grant
Start date	03/03/2003
End date	02/03/2006
Duration	36 months

Abstract

The androgen receptor (AR) is a ligand-activated transcription factor that regulates genes important for male sexual development and differentiation. Work in the applicant's laboratory has demonstrated that the AR regulates transcription during the initiation and elongation steps of the transcription cycle. Interactions with the general transcription factor TFIIF were important for initiation but not elongation control. The present proposal will delineate the role of AR- TFIIF interactions during initiation; determine if discrete regions of the AR-transactivation domain are required for initiation and elongation control; and identify the target(s) for the AR within the transcription elongation complex. These studies will exploit a novel cell-free transcription assay, using dual reporter gene templates, to functional characterise AR-protein interactions important for receptor-dependent gene regulation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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