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Dissection of the molecular interactions involved in the bacteriophage phi-29 molecular motor
Reference
C17944
Principal Investigator / Supervisor
Professor Nicola Jane Stonehouse
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Integrative & Comparative Biolog
Funding type
Research
Value (£)
161,408
Status
Completed
Type
Research Grant
Start date
13/05/2003
End date
13/05/2006
Duration
36 months
Abstract
The phi 29 DNA packaging motor is a macromolecular assembly of RNA and protein which appears to convert rotary movement into the linear translational of DNA and thus appears to be distinct from motors studied to date. Our preliminary studies have highlighted a novel macromolecular species that maybe important in motor assembly and the presence of both high and low affinity RNA binding sites on the connector protein. In the light of this data, we suggest a model for how the motor may function and propose to test this by analysis of the interactions involved at the molecular level using a wide range of biophysical techniques.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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