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Identifying mechanisms by which SOCS2 regulates signal transduction
Reference
C17863
Principal Investigator / Supervisor
Professor James Johnston
Co-Investigators /
Co-Supervisors
Institution
Queen's University of Belfast
Department
Sch of Medicine, Dentistry & Biomed Sci
Funding type
Research
Value (£)
225,072
Status
Completed
Type
Research Grant
Start date
06/03/2003
End date
28/04/2006
Duration
38 months
Abstract
The novel family of genes called the suppressors of cytokine signalling (SOCS) regulate cell proliferation and differentiation by inhibiting the function of growth factors and cytokines and accelerating the degradation of target molecules. Our aim is to understand the mechanisms by which SOCS2 can regulate signalling and regulate the degradation of other proteins. We will explore why SOCS2 functions differently from other SOCS. The interaction with elongin ubiquitin- ligase complex will also be explored using mutations in the proposed interaction region to determine how this interaction is regulated. This work will provide important insight regarding how signal transduction pathways and cell differentiation are controlled by this novel family of proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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