BBSRC Portfolio Analyser
Award details
A protein that looks like DNA! The fundamental interactions required for DNA mimicry
Reference
C17860
Principal Investigator / Supervisor
Dr David Dryden
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
164,924
Status
Completed
Type
Research Grant
Start date
01/06/2003
End date
31/05/2006
Duration
36 months
Abstract
We have solved the first structure of a protein that mimics B-form DNA. This structural mimicry enables it to inhibit totally the activity of an entire group of DNA-binding enzymes, the type I DNA restriction and modification enzymes. We wish to combine rigorous thermodynamic and kinetic approaches with protein engineering to determine how the DNA mimicry operates and to compare this novel mechanism with the normal DNA binding process of the R and M enzymes. An understanding of how DNA mimicry by proteins is achieved in structural, energetic and kinetic terms will provide a foundation for the development of a new area of proteinaceous DNA mimics to produce research tools, diagnostic tests and, possibly, therapeutic materials.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search