Award details

The biosynthesis of tail-anchored membrane proteins

Reference	C17848
Principal Investigator / Supervisor	Professor Stephen High
Co-Investigators / Co-Supervisors	Dr Benjamin Abell
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	207,144
Status	Completed
Type	Research Grant
Start date	17/02/2003
End date	17/02/2006
Duration	36 months

Abstract

Tail-anchored proteins are a special class of membrane proteins that mediate a number of key intracellular processes. In contrast to most membrane proteins, the molecular mechanisms that underlie the biosynthesis of tail-anchored proteins are poorly characterised. We have recently begun to identify cellular components that are implicated in this process. We now wish to build on this work by identifying the proteins that play a central role during the synthesis of tail-anchored proteins. The function of specific components will be addressed by using reconstituted proteoliposomes, and this in vitro analysis will be underpinned by complementary studies with semi-permeabilised mammalian cells. The outcome of this project will be a detailed understanding of the molecular basis for the biosynthesis of tail- anchored membrane proteins.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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