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Targeting of the phosphoinositide phosphatase OCRL1 to the golgi apparatus
Reference
C17842
Principal Investigator / Supervisor
Professor Martin Lowe
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
196,080
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/04/2007
Duration
43 months
Abstract
OCRL1 is a phosphatidylinositol 4,5-biosphosphate (PI(4,5)P2) 5- phosphatase whose deficiency causes Oculocerebrorenal Syndrome of Lowe, a disease affecting the brain, kidney and eyes. OCRL1 is localised to the Golgi apparatus where it is thought to play an important role in regulating membrane trafficking. The mechanism responsible for targeting of OCRL1 to the Golgi apparatus is not known. The aim of this project is to use a combination of in vitro and in vivo approaches to identify the novel Golgi targeting signalling of OCRL1 and the determinates on Golgi membranes that mediate OCRL1 recruitment. Effects of OCRL1 targeting mutants upon membrane trafficking will also be analysed to start to address the function of the protein.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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