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Award details
Identification and characterisation of proteins involved in ER redox balance
Reference
C17806
Principal Investigator / Supervisor
Professor Neil Bulleid
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
173,304
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
01/03/2006
Duration
36 months
Abstract
Proteins destined for secretions are translocated into the endoplasmic reticulum whereupon they are subjected to a variety of post- translational modifications and folding reactions prior to being transported to the Golgi apparatus. The unique environment of this organelle allows the formation and isomerisation of disulphide bonds in these newly synthesised proteins, reactions carried out by a family of oxido-reductase enzymes related to protein disulphide isomerase (PDI). The overall objective of this proposal is to isolate and characterise proteins involved in either oxidising or reducing enzymes catalysing oxidation, isomerisation or reduction of disulphide bonds within the mammalian endoplasmic reticulum.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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