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Cloning and characterisation of the first plant purinoceptors

Reference	C17526
Principal Investigator / Supervisor	Professor Julia Davies
Co-Investigators / Co-Supervisors	Dr Vadzim Dzemidchyk, Professor Beverley Jane Glover
Institution	University of Cambridge
Department	Plant Sciences
Funding type	Research
Value (£)	190,784
Status	Completed
Type	Research Grant
Start date	06/01/2003
End date	06/01/2006
Duration	36 months

Abstract

Ionotropic purinoceptors are well characterised in animal systems. These plasma membrane cation channels are gated by extracellular ATP. On opening they permit Ca2+ influx which effects signal initiation or modulation of other transporters. To date, no plant purinoceptors have been identified. We now have compelling evidence for their existence in Arabidopsis root epidermal plasmamembrane. Critically, we have also identified a putative purinoceptor protein in Arabidopsis. This project will deliver the first in planta characterisation of an ionotropic purinoceptor by continuing the electrophysiological analysis of the root isoform. The putative receptor will be characterised by heterologous expression in Xenopus. Expression pattern analysis and identification of other gene family members will complete the first step in the description of a new class of plant receptors.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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