Award details

Molecular and functional analysis of a novel epithelial junction-associated cytoskeletal protein complex

Reference	C17522
Principal Investigator / Supervisor	Professor Maria Balda
Co-Investigators / Co-Supervisors	Professor Karl Matter
Institution	University College London
Department	Institute of Ophthalmology
Funding type	Research
Value (£)	191,536
Status	Completed
Type	Research Grant
Start date	08/07/2002
End date	07/07/2005
Duration	36 months

Abstract

Tight junctions, the most apical of the epithelial cell-cell junctions, regulate paracellular diffusion as well as epithelial polarisation and differentiation. We have discovered a novel junction-associated complex that, at the immunofluorescence level, colocalises with tight junction markers. Based on preliminary data, we hypothesise that this protein complex is important for junction formation and remodelling, and thus functionally relevant during processes such as wound repair, cancer, and development of epithelial tissues. This proposal focuses on one of the proteins of this complex, a potential transmembrane protein. The aims are to complete the cDNA cloning of the protein, to determine its role in tight junction functions, and to identify the other proteins associated with the complex.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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