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Scaffolding group II metabotropic glutamate receptors
Reference
C17509
Principal Investigator / Supervisor
Professor Vincent O'Connor
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
188,468
Status
Completed
Type
Research Grant
Start date
01/10/2002
End date
30/09/2005
Duration
36 months
Abstract
Metabotropic glutamate receptors (mGluRs) provide a major route by which the neurotransmitter glutamate controls neural function. This proposal aims to identify intracellular proteins that scaffold Group II mGluRs (i.e. mGluR2 and 3). We will build on preliminary data from yeast two-hybrid (Y2H) screens that identified candidate mGluR 2 and 3 interacting proteins. Interaction specificity will be tested using Y2H and biochemical protein interaction methods. As a compliment affinity chromatography approaches will probe for potential mGluR receptor interactions. We will also use heterologous expression strategies to dissect at what level interacting proteins impact on function. Finally, we plan to use the tools developed in this proposal to investigate mGluR interacting proteins in the context of identified synapses that exhibit mGluR dependent modulation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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