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Early events in the entry of haemagglutinating echoviruses: studies to identify the novel site of uncoating
Reference
C17503
Principal Investigator / Supervisor
Dr Thomas David Kay Brown
Co-Investigators /
Co-Supervisors
Professor Paul Luzio
,
Dr Amanda Stuart
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
206,292
Status
Completed
Type
Research Grant
Start date
09/06/2003
End date
08/06/2006
Duration
36 months
Abstract
From our previous studies we have demonstrated that, in contrast to all other picornaviruses studied to date, entry by haemagglutinating echoviruses (HAEV) is exquisitely sensitive to the microtubule destabilising drug nocodazole. We propose that this sensitivity arises from the requirement by HAEV for an intracellular factor to promote uncoating of the viral RNA and the subsequent steps in viral replication. Our aims in this study are therefore to identify the subcellular compartment involved in the uncoating and how this may be linked to the site of replication of HAEV. We will also examine the intracellular trafficking route used by the virus to gain access to this compartment using dominant negative mutants of key proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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