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Investigating the mechanistic role of L-arginine in the binding and activation of molecular oxygen in NO synthase
Reference
C17500
Principal Investigator / Supervisor
Dr Simon Daff
Co-Investigators /
Co-Supervisors
Dr Tobias Ost
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
140,268
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
31/03/2005
Duration
33 months
Abstract
Mammalian nitric oxide synthase produces NO as part of a range of intercellular signalling mechanisms and as a cytotoxic agent in response to infection. It is implicated in numerous human pathogenic conditions and is an important target for selective drugs. The mechanism of NO synthesis is biochemically unique, involving the double monooxygenation of L- arginine. This programme aims to resolve important questions regarding the mechanism of oxygen activation on the molecular level by employing rational protein engineering coupled with detailed physical and chemical analysis. A clear understanding of the mechanism of NO synthesis may lead to the development of mechanism-based suicide inhibitors for use in the treatment of conditions exacerbated by overproduction of NO.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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