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Characterising the signalling mechanisms of receptor tyrosine phosphatase CRYPalpha
Reference
C17480
Principal Investigator / Supervisor
Dr Andrew Stoker
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Institute of Child Health
Funding type
Research
Value (£)
274,860
Status
Completed
Type
Research Grant
Start date
28/10/2002
End date
27/04/2006
Duration
42 months
Abstract
The receptor protein tyrosine phosphatase (RPTP) CRYPalpha:RPTPsigma regulates retinal axon growth and guidance and controls peripheral nerve maturation and repair. Our understanding of the biochemical mechanisms of CRYPalpha:RPTPsigma signalling and regulation remain critically lacking, however, and our goal here will be to advance this understanding significantly. We will establish derivatives of the neuronal cell line PC12 in which CRYPalpha expression is under inducible control. Using these cells we will identify downstream biochemical targets of CRYPalpha, determine the direct effects of extracellular ligand binding on CRYPalpha dimerisation and signalling, and address how CRYPalpha signals influence the mechanisms on axon outgrowth.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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