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Identification of factors determining transcriptional activity and specificity of NF-kB

Reference	C17457
Principal Investigator / Supervisor	Professor Ronald Hay
Co-Investigators / Co-Supervisors	Dr Rachel Evans
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	198,696
Status	Completed
Type	Research Grant
Start date	01/08/2002
End date	01/08/2005
Duration	36 months

Abstract

NF-kB transcription factor is required for regulated immune, inflammatory and survival responses, while inappropriate activation of NF-kB is associated with inflammatory disease and cancer. Events which lead to release of NF-kB into the nucleus are well documented, but those determining transcriptional activity and specificity have yet to be determined. Objectives of this work are to: identify cellular proteins associated with the p65 subunit of NF-kB after it enters the nucleus; define the role of these associated proteins in vivo; compare p65 interacting proteins under a variety of activating conditions and in the presence of inhibitors; establish which promoters are bound by p65 when NF-kB signalling is induced by different stimuli

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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