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Molecular mechanisms involved in the interleukin-6-mediated inhibition of cellular gene transcription
Reference
C17440
Principal Investigator / Supervisor
Professor Dipak Ramji
Co-Investigators /
Co-Supervisors
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
106,280
Status
Completed
Type
Research Grant
Start date
01/08/2002
End date
01/08/2004
Duration
24 months
Abstract
The cytokine interleukin-6 (IL-6) plays key roles in the immune system, acute-phase response, and in the regulation of survival, proliferation and differentiation of several cell types. The biological actions of IL-6 are characterised by both the activation and the inhibition of gene transcription. Unfortunately, in contrast to gene activation, the mechanisms through which IL-6 suppresses transcription remains largely unclear. However, using the human transcription factor C:EBPalpha as a model gene, we have recently made major advances in this important, and as yet largely neglected, area of research. The proposed project seeks to expand these findings by delineating the regulatory sequences and factors that are involved in the IL-6-mediated inhibition of gene transcription along with the signal transduction pathway(s) in operation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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