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Biological and regulatory properties of Vav-3 in B cell receptor signal transduction

Reference	C17370
Principal Investigator / Supervisor	Dr Martin Turner
Co-Investigators / Co-Supervisors	Dr Elena Vigorito
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	223,984
Status	Completed
Type	Research Grant
Start date	24/06/2002
End date	23/06/2005
Duration	36 months

Abstract

Antigen recognition by lymphocytes triggers intracellular signalling pathways that are critical for the generation of a vigorous immune response. We have obtained preliminary evidence that Vav-3 is a new molecular component of this intracellular signalling pathway. Vav-3 is a guanine nucleotide exchange factor capable of promoting monomeric GTPases to their active state. We propose to test the hypothesis that Vav3 may activate multiple signalling pathways and serve as an integrator of such pathways. This project proposes to combine molecular, cellular and genetic approaches to define the mechanism by which Vav3 functions. This integrated approach will allow us to define the unique functions of Vav-3. A fuller understanding of the role that Vav-3 plays in antigen receptor signal transduction is anticipated to contribute to new strategies for immune manipulation.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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