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Molecular and cellular analyses of the role of a myosin I in actin polymerisation cortical dynamics and cell motility

Reference	C17367
Principal Investigator / Supervisor	Professor Martin Buck
Co-Investigators / Co-Supervisors
Institution	Imperial College London
Department	Div of Biomedical Sciences
Funding type	Research
Value (£)	337,744
Status	Completed
Type	Research Grant
Start date	01/08/2002
End date	01/08/2005
Duration	36 months

Abstract

We investigate the cellular and molecular mechanisms of cell motility, a fundamental biological process, and particularly the function of actin-dependent molecular motors. We previously demonstrated that MyoK, a class I myosin from Dictyostelium, plays an important role in the maintenance of cortical tension, motility and phagocytosis. Our most recent work suggests a function as integrator of motor activity and actin dynamics. Indeed, MyoK appears to bind F-actin, the profilin-actin complex and Abp1, an actin-binding protein recently shown to activate the Arp2:3 complex, the main actin nucleator. Our strategies fully exploit this model organism and the synergy of investigating in parallel, in vivo and in vitro, the functions of MyoK.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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