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How are NMDA receptors specifically coupled to the excitotoxic cell death pathway in cerebellar granule neurons?
Reference
C17336
Principal Investigator / Supervisor
Dr Chris Connolly
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
247,564
Status
Completed
Type
Research Grant
Start date
21/10/2002
End date
20/02/2006
Duration
40 months
Abstract
Cerebellar granule neurons stimulated by excess glutamate undergo calcium influx and mitochondrial sequestration of calcium, leading to organelle dysfunction, calcium deregulation and rapid cell death by an NMDAR dependent mechanism. Vulnerability develops at P14 and may be explained by NMDAR subunit switching or changes in the expression of associated proteins specifically linking these receptors to an excitotoxic pathway. We will examine the effect of NMDAR composition on glutamate excitotoxicity. Analyses will be performed by calcium imaging and quantified using 45-calcium. Biochemical assays will probe for physical interactions between NMDARs, mitochondria and signalling molecules in an attempt to identify the mechanism involved.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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