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The role of integrin-tetraspanin complexes in activation of rho family gtpases
Reference
C17261
Principal Investigator / Supervisor
Dr Neil Hotchin
Co-Investigators /
Co-Supervisors
Dr Fedor Berditchevski
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
182,460
Status
Completed
Type
Research Grant
Start date
01/11/2002
End date
31/03/2006
Duration
41 months
Abstract
Integrin-mediated interaction with the extracellular matrix is essential to many cellular functions including proliferation, differentiation and migration. One of the key signalling events downstream of integrins involved activation of the Rho family of small GTPases, and subsequent re-organisation of the actin cytoskeleton. Tetraspanins are a recently discovered group of integrin-associated proteins shown to play an important role in signalling events mediated by the alpha3beta1 laminin receptor. We have preliminary evidence that alpha3beta1:tetraspanin complexes are involved in activation of Rho proteins. The aim of this project is to analyse the activity of the various Rho family members following the ligation of the alpha3beta1:tetraspanin complexes.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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