Award details

Regulation of the pro-apoptotic protein Bax by cell damage signals

Reference	C17197
Principal Investigator / Supervisor	Dr Guy Makin
Co-Investigators / Co-Supervisors	Professor Caroline Dive
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	227,204
Status	Completed
Type	Research Grant
Start date	12/08/2002
End date	12/08/2005
Duration	36 months

Abstract

The pro-apoptotic protein Bax is important in developmental apoptosis and in cellular response to damage signals. Bax is expressed in healthy cells, requiring activation for function. It undergoes three changes prior to cytochrome c release and apoptosis after cellular damage. Step 1 is a conformational change at the N-terminus of Bax, Step 2 is the translocation of Bax from cytosol to mitochondria and Step 3 is Bax dimerisation. However, steps 1-3 of Bax activation occur regardless of cell fate. This project will identify those events subsequent to step 3 that are required for cytochrome c release and apoptosis.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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