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The investigation of CD45 in mature lymphocyte signalling and function using conditional lineage- specific gene ablation

Reference	C17178
Principal Investigator / Supervisor	Dr Denis Alexander
Co-Investigators / Co-Supervisors	Dr Nicholas Holmes
Institution	Babraham Institute
Department	Immunology
Funding type	Research
Value (£)	286,396
Status	Completed
Type	Research Grant
Start date	02/12/2002
End date	01/10/2006
Duration	46 months

Abstract

A major outstanding question in the CD45 tyrosine phosphatase research field is to understand the molecular actions of CD45 in regulating mature peripheral non-transformed lymphocytes. The aim of this project is to generate transgenic mouse lines using cre:loxP technology enabling conditional lineage-specific ablation of the CD45 gene in both the T and B lineages. Lymphocyte development will be normal in the mouse system as CD45 will be present during lymphoid maturation. Following CD45 gene ablation, immune responses, lymphocyte proliferation, cytokine secretion and cell survival will be investigated and correlated with signal transduction analysis of antigen receptors and their key CD28:CTLA-4 and CD19:CD22 co-receptors in T and B cells.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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