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Molecular genetic analysis of growth and cell movement control by the Drosophila tumour suppressor homologue PTEN

Reference	C16865
Principal Investigator / Supervisor	Professor Clive Wilson
Co-Investigators / Co-Supervisors	Professor Deborah Charlotte Indira Goberdhan
Institution	University of Oxford
Department	Human Anatomy and Genetics
Funding type	Research
Value (£)	261,524
Status	Completed
Type	Research Grant
Start date	01/05/2002
End date	30/04/2005
Duration	36 months

Abstract

Tumour suppressor PTEN is one of the most frequently mutated genes in human cancer. We have shown that Drosophila PTEN antagonises insulin receptor signalling via its lipid phosphatase activity to restrict cell growth, a function mirrored in mammals. Here we propose to extend this analysis in flies, using molecular, cell biological, biochemical and genetic techniques. We will characterise PTEN's effects on the cytoskeleton and cell movement, determine PTEN's functions in the different subcellular compartments in which it is located, and identify molecules that bind PTEN to mediate/modulate these functions. This work should provide important insights into the in vivo mechanisms by which PTEN suppresses tumour growth in all higher organisms.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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