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An investigation into some molecular determinants of NMDA receptor-channel behaviour
Reference
C16800
Principal Investigator / Supervisor
Professor David Wyllie
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Neuroscience
Funding type
Research
Value (£)
212,296
Status
Completed
Type
Research Grant
Start date
29/04/2002
End date
29/04/2005
Duration
36 months
Abstract
In the mammalian CNS NMDA receptors mediate the slow component of fast glutamatergic excitatory synaptic currents. The rates of decay of these currents are determined by the type of NR2 subunit in the NMDA receptor complex and for how long glutamate remains bound to its receptor. Interestingly, the expression of NR2 NMDA subunits is temporally and spatially regulated, suggesting that alterations in the decay rates of NMDA receptor- mediated currents is either critical for, or a consequence of, plasticity in the CNS. Detailed single-channel data characterising mutations that alter deactivation rates are lacking. This proposal, through a combination of site- directed mutagenesis and electrophysiology will characterise mutations in S1 and S2 binding domains and will assess the consequences of expressing such mutants in neurones.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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