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The role of envoplakin periplakin and involucrin in keratinocyte differentiation and skin barrier function
Reference
C16790
Principal Investigator / Supervisor
Dr Arto Maatta
Co-Investigators /
Co-Supervisors
Institution
Durham University
Department
Biological and Biomedical Sciences
Funding type
Research
Value (£)
204,848
Status
Completed
Type
Research Grant
Start date
01/12/2002
End date
01/12/2005
Duration
36 months
Abstract
The functional endpoint of keratinocyte differentiation in cornified envelope (CE), a cross-linked protective protein layer in the outermost cell layers of the skin. Plakins and involucrin have a central role in the current models of CE assembly as they are implicated in the formation of initial scaffold between desmosomes. However, none of the corresponding single knock-out animals have pathological changes in their epidermis indicating redundancy in the envelope assembly. To understand CE assembly we will analyse epidermal differentiation and function in three different double knock-out mice models that lack CE precursors envoplakin and periplakin, envoplakin and involucrin, or periplakin and involucrin, respectively. We will also screen for up-regulation of other precursor proteins that can compensate for the loss of these proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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