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Cytolethal distending toxin (CDT): transcriptional control and mechanism of cellular uptake

Reference	C16749
Principal Investigator / Supervisor	Professor Brian Henderson
Co-Investigators / Co-Supervisors	Dr Sean Nair, Dr Gudrun Stenbeck
Institution	University College London
Department	Eastman Dental Institute
Funding type	Research
Value (£)	165,436
Status	Completed
Type	Research Grant
Start date	05/08/2002
End date	05/08/2005
Duration	36 months

Abstract

Cytolethal distending toxin (CDT) is a bacterial toxin encoded by three separate genes (cdtA, cdtB, cdtC) that acts to arrest eukaryotic cell cycle progression in G2. It is not known how the genes controlling this toxin are controlled by environmental factors. Controversy exists as to the active toxin component, with CdtB or CdtC being claimed to be the active moiety. Our own data suggests that hypothesis that CdtC acts as a carrier for the internalisation of CdtB. The objectives of this proposal are to: (i) identify how cdt transcription is controlled by the bacterium's environment; (ii) ascertain the mechanism of cellular uptake of CdtB and CdtC and (iii) define the structure-function relationships of CdtB and CdtC.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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