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Molecular characterisation of S. pneumoniae topoisomerase IV and gyrase complexes and their interactions with quinolones
Reference
C16747
Principal Investigator / Supervisor
Professor Larry Mark Fisher
Co-Investigators /
Co-Supervisors
Dr Mark Sanderson
Institution
St George's University of London
Department
Biochemistry & Immunology
Funding type
Research
Value (£)
360,304
Status
Completed
Type
Research Grant
Start date
01/02/2002
End date
28/02/2005
Duration
37 months
Abstract
Antipneumococcal fluoroquinolones are active against penicillin- and multidrug-resistant Streptococcus pneumoniae. We have shown that, unusually for bacteria, these quinolones can differentially activate DNA cleavage and cell killing through topoisomerase IV or DNA gyrase in S. pneumoniae. By a combination of enzymatic studies and by high resolution structural analysis of S. pneumoniae enzyme domains, we aim to define the molecular determinants that govern topoisomerase interactions with quinolones and DNA. These studies will provide new mechanistic information on two key antipneumococcal targets and facilitate the design of dual targeting agents that help circumvent resistance development.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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