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The role of SHP1 in haemopoietic differentiation of embryonic stem cells

Reference	C16707
Principal Investigator / Supervisor	Professor Melanie Welham
Co-Investigators / Co-Supervisors
Institution	University of Bath
Department	Pharmacy and Pharmacology
Funding type	Research
Value (£)	170,228
Status	Completed
Type	Research Grant
Start date	28/01/2002
End date	27/06/2005
Duration	41 months

Abstract

Cytokines play a critical role during development of the haemopoietic system but the importance of the intracellular signals they activate during self-renewal, expansion and differentiation are not well understood. This study will investigate the role of the tyrosine phosphatase, SHP1, during haemopoiesis using a murine embryonic stem cell line as an in vitro model. Regulated expression of variant forms of SHP1 in E14tg2a ES cells will allow examination of the role of SHP1 in self-renewal, cytokine-induced differentiation, progenitor cell proliferation and survival to be determined. A combination of cellular and molecular analyses will be used in these investigations to examine effects on both cell biology and the underlying biochemistry.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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