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Characterisation of a vesicle-associated cell cycle-regulated microtubule motor
Reference
C16691
Principal Investigator / Supervisor
Professor Viki Allan
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
208,148
Status
Completed
Type
Research Grant
Start date
01/09/2002
End date
01/09/2005
Duration
36 months
Abstract
Although many members of the kinesin family of microtubule motors have been identified using molecular approaches, few of these motors are understood at the cell biological level, either in terms of what cargo they transport, or how their function is regulated. Our aim is to use a functional assay in combination with protein purification and proteomics approach to identify and characterise a kinesin-related protein (KRP) that drives the movement in vitro of vesicles derived from a Golgi membrane fraction. We have previously shown that this motility is under cell cycle control, and so this provides an excellent model system for investigating the regulation of a microtubule plus end-directed motor.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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