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Molecular basis of the formation of an N-cadherin/FGF receptor signalling complex and development of peptide agonists

Reference	C16476
Principal Investigator / Supervisor	Professor Patrick Doherty
Co-Investigators / Co-Supervisors
Institution	King's College London
Department	GKT School of Medicine
Funding type	Research
Value (£)	256,296
Status	Completed
Type	Research Grant
Start date	01/07/2002
End date	01/07/2005
Duration	36 months

Abstract

Studies of N-cadherin function in axonal growth, cell survival and tumour cell migration suggest that the formation of a signalling complex between N-cadherin and the FGF receptor (FGFR) is involved in each response. We have recently identified a motility motif in ECD4 of N-cadherin that can interact with the HAV region of the FGFR, and developed immunoprecipitation and co-clustering paradigms that allow us to measure interactions between the two molecules. We now propose to determine the factors that regulate association of the FGFR with N-cadherin, the specificity of this interaction in the context of the other classical cadherins, and to determine if peptides can trigger the activation of the signalling complex in neurons and other cells.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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