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Bicarbonate mediated signal transduction in Cyanobacteria
Reference
C16396
Principal Investigator / Supervisor
Professor Martin Cann
Co-Investigators /
Co-Supervisors
Institution
Durham University
Department
Biological and Biomedical Sciences
Funding type
Research
Value (£)
186,500
Status
Completed
Type
Research Grant
Start date
23/09/2002
End date
22/03/2006
Duration
42 months
Abstract
Bicarbonate ion is a novel signalling molecule that stimulates the production of cAMP via the mammalian soluble adenylyl cyclase. Adenylyl cyclase bicarbonate responsiveness is also conserved in cyanobacteria. The aim of this proposal is to utilise the model cyanobacterium Synechocystis sp. PCC6803 to demonstrate the physiological relevance of bicarbonate ion signal transduction in a biologically meaningful environment. This will be achieved by a combination of molecular, enzymological, and phenotypic analysis and will provide the first evidence for the relevance of bicarbonate mediated signal transduction in the animal kingdom. This may have important consequences for our understanding of bicarbonate function in eukaryotes.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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