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Novel interactions of oxysterol binding protein- related proteins (ORPs) in the secretory pathway
Reference
C15982
Principal Investigator / Supervisor
Dr Timothy Levine
Co-Investigators /
Co-Supervisors
Dr David Owen
Institution
University College London
Department
Institute of Ophthalmology
Funding type
Research
Value (£)
196,436
Status
Completed
Type
Research Grant
Start date
01/12/2001
End date
31/05/2005
Duration
42 months
Abstract
The family of oxysterol binding protein-related proteins (ORPs) carries out a fundamental role in intracellular lipid transport. Following advances in human genomics, the human ORP family is now known at have 12 members, with two novel features. These features have important implications beyond the ORP family for intracellular lipid traffic in general, and they will be the focus of our work. Firstly, we will examine the molecular interactions of the ankyrin repeats in Osh1p and ORP1, to identify conserved aspects of the nucleus-vacuole junction. Secondly, the localisation of ORPs with trans- membrane domains will be dissected, as the combination of these domains with other ORP targeting domains suggests a novel mechanism of protein sorting.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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