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The role of paxillin in chemotactic cell movement; an analysis of its effect on traction and adhesion forces
Reference
C15874
Principal Investigator / Supervisor
Professor Kees Weijer
Co-Investigators /
Co-Supervisors
Dr Bakhtier Vasiev
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
269,844
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2004
Duration
36 months
Abstract
A key question in understanding how cells move in a tissue is how they gain traction from neighbouring cells. Paxillin is a major player in this process since it controls the coupling of the actin-cytoskeleton to adhesion complexes. A paxillin (paxB) null mutant generated in the social amoebae Dictyostelium discoideum is severely impaired in multicellular development. We will investigate the role that the strongly conserved LD and LIM domains and their modifications play in chemotactic cell movement during its multicellular development. To assess the role of paxB in the cells force transducing systems we will establish and develop methods to measure quantitatively the forces between cells and substrates of different composition.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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