Award details

Molecular aspects of integrin specificity of foot and mouth disease virus

Reference	C15845
Principal Investigator / Supervisor	Dr Terry Jackson
Co-Investigators / Co-Supervisors	Dr Andrew King
Institution	The Pirbright Institute
Department	Div of Molecular Biology
Funding type	Research
Value (£)	174,148
Status	Completed
Type	Research Grant
Start date	18/01/2002
End date	17/03/2005
Duration	38 months

Abstract

Foot-and-mouth disease virus (FMDV), the highly infectious pathogen of cloven-hoofed animals, infects cells by attaching to integrin receptors through a conserved RGD tripeptide. Several integrins bind RGD ligands, but only one of these, alpha v beta 6, appears from this Group's current research to be an efficient receptor for FMDV in nature. The choice is highly significant as alpha v beta 6 is expressed only in epithelial tissues, and normally only at low levels. We wish to determine how, in terms of sequence and structure, FMDV recognises alpha v beta 6. The work will further our understanding of the pathology of FMDV infections, both acute and persistent, and will underpin any future development of anti-FMDV agents based on receptor blockade.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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