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Regulation of precursor cell proliferation during B lymphocyte development
Reference
C15831
Principal Investigator / Supervisor
Dr Inga-Lill Martensson-Bopp
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Developmental Genetics and Imprinting
Funding type
Research
Value (£)
221,936
Status
Completed
Type
Research Grant
Start date
15/10/2001
End date
14/02/2005
Duration
40 months
Abstract
As part of the normal development of B lymphocytes, a crucial proliferative expansion takes place in the bone marrow. The cells that participate in this process are the precursor B cells, but they can only proliferate if they express the pre-B cell receptor. We have shown that in the absence of one of the receptor components, the Ig surrogate light (SL) chain less than 2 percent of the normal number of B cells develop. We propose that upon cell surface expression the pre-BCR delivers two signals to the cell: (i) entry into the cell cycle, and (ii) switching off SL gene transcription ensuring that proliferation is ultimately terminated due to lack of SL chain protein. We propose to test whether such a mechanism functions to regulate pre-B cell proliferation by correlating SL gene transcription and protein levels with proliferation in normal and knock out mice and in tet-transgenic mice where we can control the levels of SL chain precisely.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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