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Applying proteomics to distinguish unique mediators of Myc-induced growth or apoptosis in adult tissues in vivo
Reference
C15763
Principal Investigator / Supervisor
Dr Michael Khan
Co-Investigators /
Co-Supervisors
Professor H Dalton
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
201,448
Status
Completed
Type
Research Grant
Start date
08/04/2002
End date
07/07/2005
Duration
39 months
Abstract
Activating c-Myc in switchable transgenic mice (MycER) promotes both proliferation and apoptosis; which predominates is dictated by survival signals. Suppressing Myc-induced apoptosis results in the emergence of invasive neoplasia. However, specific changes in protein/gene expression mediating distinct Myc actions in vivo are unknown. Therefore, using the unique MycER system, immediate and delayed consequences of Myc activation in vivo will be examined. Proteome analysis and microarray techniques will be used to determine specific mediators of the following Myc-induced phenotypes: tissue involution; tissue growth and subsequent transition to invasive neoplasia. Finally, mediators of phenotype reversal will be determined.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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