BBSRC Portfolio Analyser
Award details
Comparative mechanistic studies on 1 zinc and 2 zinc metallo-beta-lactamases
Reference
C15746
Principal Investigator / Supervisor
Dr Timothy Walsh
Co-Investigators /
Co-Supervisors
Professor Anthony Clarke
Institution
University of Bristol
Department
Cellular and Molecular Medicine
Funding type
Research
Value (£)
158,212
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2004
Duration
36 months
Abstract
This project will involve a detailed study of substrate binding and enzyme mechanism for three phylogenetically diverse metallo-beta-lactamases; L1, ImiS and IMP-1. This project is a synthesis of structural and kinetic information (steady- and pre-steady state) with a view to identifying how the reaction pathway is influenced by antibiotic (substrate) and enzyme structure. The data generated will extend and answer questions on existing hypotheses proposed by the project Group on their mechanistic pathways. The data generated will 1) be of value in future inhibitor design, 2) establish how metallo-beta-lactamases can hydrolyse a wide range of different substrates and 3) give an insight into other metallo-enzymes with similar active sites.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search