Award details

The function of Sec 1 proteins in exocytosis

Reference	C15706
Principal Investigator / Supervisor	Professor Alan Morgan
Co-Investigators / Co-Supervisors	Professor Robert Burgoyne
Institution	University of Liverpool
Department	Physiology
Funding type	Research
Value (£)	338,092
Status	Completed
Type	Research Grant
Start date	02/04/2002
End date	01/07/2005
Duration	39 months

Abstract

Intracellular membrane fusion events are thought to occur by a similar mechanism in all eukaryotic organisms. This process requires Sec 1 proteins, a ubiquitous protein family that is essential for membrane trafficking. Although the requirement for Sec 1 proteins is not in question, their function (s) in the fusion process is not clear. Our proposal is to shed light on this issue by a combination of molecular, genetics, biochemistry and electrophysiology. Mutational screens in yeast will be used to identify novel sec1 mutations and biochemical assays employed to reveal the underlying defects in the mutant proteins. Information on these novel mutations will be pooled with that from known Sec1 mutations in flies and worms, and their effects on membrane fusion in mammalian cells determined by biochemical and electrophysiological techniques. (Joint with grant 15/C15710).

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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