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Molecular mechanism of drug transport by LmrA the bacterial homolog of the human multidrug resistance P-glycoprotein
Reference
C15670
Principal Investigator / Supervisor
Professor Hendrik Willem van Veen
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
188,496
Status
Completed
Type
Research Grant
Start date
12/11/2001
End date
12/11/2004
Duration
36 months
Abstract
ATP-binding cassette transporters are associated with many human disease phenotypes including multidrug resistance, adrenoleukodystrophy and Tangier disease. Insight into the mechanism of ABC transporters is vital for our ability to develop new drugs which can alter or circumvent the activity of these proteins. Recent evidence suggests that LmrA, the bacterial homolog of P- glycoprotein, mediates multidrug transport from the membrane by a two-cylinder engine mechanism. LmrA harbors two drug binding sites on opposite sides of the membrane which are interconverted in an ATP-dependent fashion. The aim of this proposal is to further test this mechanism by studying the link between ATP binding/hydrolysis, and the interaction of drugs with LmrA.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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