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Regulation of clathrin coated vesicle formation by AP2 phosphorylation
Reference
C15666
Principal Investigator / Supervisor
Professor Elizabeth Smythe
Co-Investigators /
Co-Supervisors
Dr David Owen
Institution
University of Sheffield
Department
Medicine and Biomedical Science
Funding type
Research
Value (£)
182,424
Status
Completed
Type
Research Grant
Start date
25/11/2002
End date
25/11/2005
Duration
36 months
Abstract
The clathrin coated pit is the major port of entry for many receptors and pathogens and is the paradigm for membrane-based sorting events in higher cells. The plasma membrane AP2 complex plays a key role in clathrin coated pit function, providing a link between clathrin and the membrane and also interacting with many other molecules essential for endocytosis. AP2 has been shown to be phosphorylated in vivo and in vitro. The aim of this proposal is to study the regulation of receptor- mediated endocytosis by AP2 phosphorylation. The methodology will include a systematic biochemical analysis of phosphorylation sites coupled to a functional cell biological approach using both biochemical and morphological studies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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