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Role of JNK MAP kinase in the response of astrocytes to TNF alpha
Reference
C15588
Principal Investigator / Supervisor
Dr Cathy Tournier
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
189,896
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2005
Duration
36 months
Abstract
The overall aim of this project is to understand how the JNK signalling pathway mediates the reactive response of astrocytes to TNF alpha. Primary cultures of astrocytes lacking the mkk7 gene will be employed. Preliminary results indicate that mkk7-/- astrocytes will be specifically deficient in TNF alpharoteininduced JNK activation. The role of the JNK signalling pathway in TNF alpha-stimulated astrocyte proliferation, cytokine production, survival, and anti-apoptotic signalling will be determined through a gain or loss of function. Genes implicated in the response of astrocytes to TNF alpha will be identified by DNA array analysis. These studies will provide a direct link between TNF alpha, the JNK signalling pathway, gene expression, and astrocyte physiology.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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